IndyCar 2021 Indy 500
| # | Driver | Team | Car | Engine | Tyres | |
|---|---|---|---|---|---|---|
| 1 | J.R. Hildebrand | A.J. Foyt Enterprises | Dallara DW12 | Chevrolet | Firestone | |
| 2 | Josef Newgarden | Team Penske | Dallara DW12 | Chevrolet | Firestone | |
| 3 |  Scott McLaughlin | Team Penske | Dallara DW12 | Chevrolet | Firestone | |
| 4 |  Dalton Kellett | A.J. Foyt Enterprises | Dallara DW12 | Chevrolet | Firestone | |
| 5 |  Patricio O'Ward | Arrow McLaren SP | Dallara DW12 | Chevrolet | Firestone | |
| 06 |  Helio Castroneves | Meyer Shank Racing | Dallara DW12 | Honda | Firestone | |
| 7 |  Felix Rosenqvist | Arrow McLaren SP | Dallara DW12 | Chevrolet | Firestone | |
| 8 | Marcus Ericsson | Chip Ganassi Racing | Dallara DW12 | Honda | Firestone | |
| 9 | Scott Dixon | Chip Ganassi Racing | Dallara DW12 | Honda | Firestone | |
| 10 |  Alex Palou | Chip Ganassi Racing | Dallara DW12 | Honda | Firestone | |
| 11 | Charlie Kimball | A.J. Foyt Enterprises | Dallara DW12 | Chevrolet | Firestone | |
| 12 |  Will Power | Team Penske | Dallara DW12 | Chevrolet | Firestone | |
| 14 |  Sébastien Bourdais | A.J. Foyt Enterprises | Dallara DW12 | Chevrolet | Firestone | |
| 15 | Graham Rahal | Rahal Letterman Lanigan Racing | Dallara DW12 | Honda | Firestone | |
| 16 |  Simona de Silvestro | Paretta Autosport | Dallara DW12 | Chevrolet | Firestone | |
| 18 |  Ed Jones | Dale Coyne Racing | Dallara DW12 | Honda | Firestone | |
| 20 | Ed Carpenter | Ed Carpenter Racing | Dallara DW12 | Chevrolet | Firestone | |
| 21 |  Rinus van Kalmthout | Ed Carpenter Racing | Dallara DW12 | Chevrolet | Firestone | |
| 22 | Simon Pagenaud | Team Penske | Dallara DW12 | Chevrolet | Firestone | |
| 24 | Sage Karam | Dreyer & Reinbold Racing | Dallara DW12 | Chevrolet | Firestone | |
| 25 |  Stefan Wilson | Andretti Autosport | Dallara DW12 | Honda | Firestone | |
| 26 | Colton Herta | Andretti Autosport | Dallara DW12 | Honda | Firestone | |
| 27 | Alexander Rossi | Andretti Autosport | Dallara DW12 | Honda | Firestone | |
| 28 | Ryan Hunter-Reay | Andretti Autosport | Dallara DW12 | Honda | Firestone | |
| 29 | James Hinchcliffe | Andretti Autosport | Dallara DW12 | Honda | Firestone | |
| 30 |  Takuma Sato | Rahal Letterman Lanigan Racing | Dallara DW12 | Honda | Firestone | |
| 45 | Santino Ferrucci | Rahal Letterman Lanigan Racing | Dallara DW12 | Honda | Firestone | |
| 47 | Conor Daly | Ed Carpenter Racing | Dallara DW12 | Chevrolet | Firestone | |
| 48 | Tony Kanaan | Chip Ganassi Racing | Dallara DW12 | Honda | Firestone | |
| 51 | Pietro Fittipaldi | Dale Coyne Racing | Dallara DW12 | Honda | Firestone | |
| 59 | Max Chilton | Carlin | Dallara DW12 | Chevrolet | Firestone | |
| 60 | Jack Harvey | Meyer Shank Racing | Dallara DW12 | Honda | Firestone | |
| 75 | R.C. Enerson | Top Gun Racing | Dallara DW12 | Chevrolet | Firestone | |
| 86 |  Juan Pablo Montoya | Arrow McLaren SP | Dallara DW12 | Chevrolet | Firestone | |
| 98 | Marco Andretti | Andretti Herta-Haupert with Marco & Curb-Agajanian | Dallara DW12 | Honda | Firestone |