It was Dani Pedrosa who commanded the early stages after a lightning getaway from fourth on the grid, with Marquez slotting into second ahead of the two factory Yamahas of Valentino Rossi and Vinales.

But Vinales fell out of contention on the second lap of 21 with a low-side crash at Turn 18, ending the Spaniard's winning streak after his victories in Qatar and Argentina.

That left Rossi alone against the Repsol Honda duo at the head of the field, with Pedrosa keeping Marquez bottled up until the eighth lap, when Marquez made an unsuccessful attempt to pass Pedrosa at Turn 11.

The following lap Marquez was able to make the move stick, with Pedrosa - who unlike Marquez opted for a medium front tyre instead of a hard - initially staying close to his teammate.

But by the end of the 14th lap, Marquez had pulled a second clear, and from there he steadily increased the gap out front to win by 3.069s - scoring his first win of the year, his 30th in the premier class, and keeping his perfect record of MotoGP wins in the USA intact.

Behind, Pedrosa soon came under pressure from Rossi in the battle for second, with the Italian having earlier been handed a 0.3s time penalty for cutting the track and gaining an advantage on Lap 7.

The sanction came when Tech 3 rider Johann Zarco tried to force his way by Rossi at Turn 4, which resulted in the seven-time premier class champion gaining ground on Marquez ahead.

Rossi's penalty didn't affect his result though, as he passed Pedrosa at Turn 19 with three laps remaining and pulled away from the Honda rider to the tune of two seconds.

With 56 points from the first three races, Rossi now leads the championship by six from Vinales, with Marquez moving up to third on 38 points.

Cal Crutchlow (LCR Honda) passed Zarco on the penultimate lap to claim fourth, a further 2.5s back, while Andrea Dovizioso was the top Ducati rider in sixth.

His teammate Jorge Lorenzo ran seventh for much of the race, but faded to ninth behind Andrea Iannone (Suzuki) and Danilo Petrucci (Pramac Ducati) in the closing stages.

Jack Miller (Marc VDS Honda) completed the top 10 ahead of the second Tech 3 Yamaha of Jonas Folger and Scott Redding's Pramac Ducati.

Besides Vinales, Karel Abraham (Aspar Ducati), Loris Baz (Avintia Ducati), Sam Lowes (Aprilia) and Alvaro Bautista (Aspar Ducati) all crashed, although the last-named was able to remount to beat Bradley Smith's KTM to the final point.

The sister KTM of Pol Espargaro was an early retirement with a clutch problem.

Aleix Espargaro's Aprilia also made a mid-race visit to the pits with an apparent front tyre problem, and resumed to come home 17th and last of the finishers.

Pos.	#	Rider	Bike	Time/Gap
1	93	Marc Marquez	Honda	43'58.770
2	46	Valentino Rossi	Yamaha	3.069
3	26	Dani Pedrosa	Honda	5.112
4	35	Cal Crutchlow	Honda	7.638
5	5	Johann Zarco	Yamaha	7.957
6	4	Andrea Dovizioso	Ducati	14.058
7	29	Andrea Iannone	Suzuki	15.491
8	9	Danilo Petrucci	Ducati	16.772
9	99	Jorge Lorenzo	Ducati	17.979
10	43	Jack Miller	Honda	18.494
11	94	Jonas Folger	Yamaha	18.903
12	45	Scott Redding	Ducati	28.735
13	53	Tito Rabat	Honda	30.041
14	8	Hector Barbera	Ducati	31.364
15	19	Alvaro Bautista	Ducati	1'06.547
16	38	Bradley Smith	KTM	1'22.090
17	41	Aleix Espargaro	Aprilia	2 laps
Ret	22	Sam Lowes	Aprilia	10 laps
Ret	44	Pol Espargaro	KTM	12 laps
Ret	76	Loris Baz	Ducati	13 laps
Ret	25	Maverick Viñales	Yamaha	20 laps
Ret	17	Karel Abraham	Ducati	20 laps