Scott Redding will move across from his current Marc VDS Honda team to race for Pramac Ducati next season.
The British rider had been linked to the satellite Ducati team in the wake of his struggles to get to grips with the factory-spec Honda RC213V in 2015, having taken only two top 10 finishes so far this year.
Redding, 22, will line up alongside Danilo Petrucci in 2016 for his third premier class campaign, replacing Yonny Hernandez, who is expected to move across from Pramac to join Hector Barbera at Avintia Racing.
The official statement from the Pramac team read: "Octo Pramac Racing wishes to announce that it has reached an agreement with the British rider Scott Redding, who will race for the Italian team in the 2016 MotoGP World Championship on a Ducati Desmosedici GP."
Moto3 points leader Danny Kent had also been linked to the Pramac ride, having been offered a three-year deal to graduate directly to the premier class with the team, but it is now expected he will take the more conventional route of stepping up to Moto2 with his current Leopard Racing team.